When someone struggles with depression, anxiety, or PTSD, finding the right treatment can make all the difference. While traditional antidepressants have helped many people for decades, newer options such as ketamine-assisted therapy are providing hope for those who haven’t found relief through conventional methods.

At Milestone Recovery in Mesa, we offer ketamine-assisted therapy as part of a comprehensive mental health program. Understanding how it compares to traditional antidepressants can help you make informed decisions about your care — especially when it comes to timelines, expectations, and outcomes.

How Traditional Antidepressants Work

Traditional antidepressants — such as SSRIs (Selective Serotonin Reuptake Inhibitors) and SNRIs (Serotonin-Norepinephrine Reuptake Inhibitors) — work by balancing chemicals in the brain related to mood regulation. Over time, these medications can help reduce symptoms of depression and anxiety by increasing the availability of serotonin and other neurotransmitters.

However, antidepressants typically take four to six weeks to reach full effect. In some cases, patients may need to try multiple medications before finding the right fit. While these treatments are effective for many people, the process can feel slow and frustrating for those seeking faster relief.

How Ketamine Works Differently

Ketamine, originally developed as an anesthetic, works through a unique mechanism that targets glutamate, a neurotransmitter involved in mood, learning, and memory. Unlike antidepressants that focus solely on serotonin or norepinephrine, ketamine helps form new neural connections — essentially helping the brain “rewire” itself toward healthier thought patterns.

At Milestone Recovery, ketamine is administered in a controlled, therapeutic setting as part of a larger treatment plan that includes talk therapy, mindfulness, and ongoing mental health support. This integration helps clients process emotions safely while maximizing ketamine’s benefits.

Timelines: Ketamine vs. Traditional Antidepressants

One of the most significant differences between ketamine and traditional antidepressants is the timeline of relief.

While ketamine works quickly, it’s often used as part of a broader plan — not as a replacement for therapy or long-term lifestyle changes. Meanwhile, traditional antidepressants can offer steady improvement for those whose symptoms respond to serotonin-based treatment.

Expectations During Treatment

Ketamine-Assisted Therapy

Clients typically receive a series of ketamine sessions over several weeks. Each session takes place under professional supervision in a calm, supportive setting. The experience is combined with therapy to help integrate insights and emotional processing.

Most clients notice improved mood, reduced anxiety, and renewed motivation within days. However, follow-up care and maintenance sessions may be recommended to sustain progress.

Traditional Antidepressants

With antidepressants, improvement builds gradually. Clients may start to feel lighter or more focused after a few weeks, but consistent use is essential. Regular check-ins with a prescriber help monitor side effects and dosage adjustments.

Both approaches require patience, but the right one depends on the individual’s mental health history, goals, and medical needs.

Combining Therapies for Better Outcomes

At Milestone Recovery, we often combine ketamine-assisted therapy with traditional treatments like CBT, DBT, or medication management. This integrated approach addresses both biological and emotional healing — creating long-term stability and reducing the risk of relapse.

When guided by experienced clinicians, combining modalities can lead to faster, more sustainable results. Our Mesa team carefully tailors every plan to meet each client’s unique needs.

Why Mesa Residents Choose Milestone Recovery

Milestone Recovery proudly serves Mesa and surrounding Valley communities, including Phoenix, Scottsdale, Chandler, Gilbert, Tempe, Paradise Valley, Fountain Hills, Cave Creek, and Glendale.

Our licensed clinicians provide personalized, compassionate care that blends science and empathy. Whether you’re exploring ketamine-assisted therapy or continuing with traditional antidepressant treatment, our team helps you navigate your options with clarity and confidence.

Take the Next Step Toward Relief

If you’re struggling with depression or anxiety and haven’t found success with traditional medications, ketamine-assisted therapy in Mesa may offer new hope. At Milestone Recovery, we provide safe, evidence-based treatments that empower you to heal — mentally, emotionally, and physically.

Call today at (480) 630-7234 to schedule your free estimate!